95579-17-2Relevant academic research and scientific papers
Design, synthesis, and pharmacological characterization of N - And O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: Novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties
Jensen, Anders A.,Plath, Niels,Pedersen, Martin H. F.,Isberg, Vignir,Krall, Jacob,Wellendorph, Petrine,Stensb?l, Tine B.,Gloriam, David E.,Krogsgaard-Larsen, Povl,Fr?lund, Bente
, p. 1211 - 1227 (2013/03/28)
The isoxazol-3-one tautomer of the bicyclic isoxazole, 5,6,7,8-tetrahydro- 4H-isoxazolo[4,5-d]azepin-3-ol (THAZ), has previously been shown to be a weak GABAA and glycine receptor antagonist. In the present study, the potential in this scaffold
Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems
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, (2008/06/13)
The present invention relates to novel compounds of the following formula: STR1 individual isomers and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; R2 is alkyl, alkenyl, alkynyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; and R4 is hydrogen or alkyl. The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of the formula I.
