95579-30-9Relevant articles and documents
Simple and Condensed β-Lactams. Part 23. Synthesis of Some Compounds Related to the Monobactams, Carrying Non-Acylamino Substituents in Position 3 and Various Heterocyclyl or Heterocyclylmethyl Substituents in Position 4 of the β-Lactams Ring
Fetter, Jozsef,Bertha, Ferenc,Czuppon, Tibor,Kajtar-Peredy, Maria,Lempert, Karoly
, p. 2738 - 2789 (2007/10/03)
Racemic monobactam analogues 8a-8c, 8e-8g, 8n, 27, 44k-44m, 48c and 51d, carrying hydrogen or non-acylamino substituents in position 3, and 2-substituted thiazol-4-yl, 2-substituted thiazol-4-ylmethyl, 4-substituted yhiazol-2-ylmethyl, 2-benzyltetrazol-5-ylmethyl or 5-methoxyisoxazol-3-ylmethyl substituents in position 4 of the β-lactam ring, as well as the reversed monobactam 35 were synthesised.None of the compounds synthesised exhibited any microbiological activities.Base catalyzed rearrangement of a 4-cyanomethylazetidin-2-one (39j) into a 6-aminopyridin-2(1H)-one (40) and acid catalyzed rearrangements, with elimination of the lactam nitrogen atoms, of two 4-(thiazol-2-ylmethyl)azetidin-2-ones (44a, 44b) into a thiazolopyridinone (47) were observed.