955879-83-1Relevant academic research and scientific papers
The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors
Graham Robinett,Freemerman, Alex J.,Skinner, Michael A.,Shewchuk, Lisa,Lackey, Karen
, p. 5886 - 5893 (2007)
Substituted 4-(3-hydroxyanilino)-quinoline compounds, initially identified as small-molecule inhibitors of src family kinases, have been evaluated as potential inhibitors of RET kinase. Three compounds, 38, 31, and 40, had Ki's of 3, 25, and 50
AMINO-QUINOLINES AS KINASE INHIBITORS
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Page/Page column 70, (2018/06/22)
Disclosed are compounds having the formula:wherein R 1 , R 2 , R 3 and Z are as defined herein, and methods of making and using the same.
AMINO-QUINOLINES AS KINASE INHIBITORS
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Page/Page column 81, (2018/05/15)
Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
SUBSTITUTED QUINOXALINE DERIVATIVES
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Page/Page column 147, (2016/11/28)
The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.
AMINO-QUINOLINES AS KINASE INHIBITORS
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Paragraph 0137; 0138, (2016/10/31)
Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
Compounds and Methods of Treatment
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Page/Page column 21, (2008/12/08)
A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.
