955948-60-4

Upstream product

• 905312-49-4 (+)-(2R)-methyl 2-(p-methoxybenzyloxy)propanoate 
• 955948-59-1 C₃₂H₃₄O₅ 
• 1006058-80-5 (4R)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolane 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 218435-12-2 (2R)-2-[(4-methoxybenzyl)oxy]propanal 
• 1623063-15-9 (2R,3R,4S)-4-butyl-2-(4-methoxybenzyloxy)hexa-5-en-3-ol 
• 1623063-16-0 (2R,3R,4S)-4-butyl-2-(4-methoxybenzyloxy)hexa-5-en-3-yl 3-methylbutanoate 
• 1623063-22-8 (2R,3R,4S)-3-benzyloxy-2-(4-methoxybenzyloxy)-4-butylhexa-5-ene 

Relevant academic research and scientific papers

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative

In response to various exogenous stimuli, mast cells (MCs) release a wide variety of inflammatory mediators stored in their cytoplasmic granules and this release initiates subsequent allergic reactions. Lysophosphatidylserine (lysoPS) has been known as an exogenous inducer to potentiate histamine release from MCs, though even at submicromolar concentrations. In this study, through SAR studies on lysoPS against MC degranulation, we identified lysoPT, a threonine-containing lysophospholipid and its 2-deoxy derivative as novel strong agonists. LysoPT and its 2-deoxy derivative induced histamine release from MCs both in vitro and in vivo at a concentration less than one-tenth that of lysoPS. Notably, lysoPT did not activate a recently proposed lysoPS receptor on MCs, GPR34, demonstrating the presence of another undefined receptor reactive to both lysoPS and lysoPT that is involved in MC degranulation. Thus, the present strong agonists, lysoPT and its 2-deoxy derivative, will be useful tools to understand the mechanisms of lysoPS-induced activation of degranulation of MCs. 2009 American Chemical Society.

Stereoselective total synthesis of (-)-aspinolide B from (R)-2,3-O-isopropylideneglyceraldehyde

A stereoselective total synthesis of (-)-aspinolide B by a convergent strategy is reported. Georg Thieme Verlag Stuttgart.

Streamlined, asymmetric synthesis of 8,4′-oxyneolignans

Highly direct, modular syntheses of several natural 8,4′- oxyneolignans [(-)-1, (+)-1, (-)-2, and (-)-3] and some related variants [(-)-26, (+)-26, (+)-27, and (-)-28] are reported. Utilizing (S)- or (R)-methyl lactate as the chiral sources, two complementary syn- or anti-oriented routes were designed, encompassing nine and five steps, which were carried out to deliver the targets in an enantiomerically pure form. The embodiment of the two independent aryl and aryloxy moieties onto the lactate frame was performed according to a diversity-oriented protocol from the common precursors, aldehydes 6 and ent-6 for the syn-oriented routes and mesyl esters 19 and ent-19 for the anti-oriented routes. These syntheses set the stage for the generation of a wide and diverse repertoire of 8,4′-oxyneolignan compounds and the broad biological interrogation of its members.