955951-04-9Relevant academic research and scientific papers
Enantioselective synthesis of syn / anti -1,3-amino alcohols via proline-catalyzed sequential α-aminoxylation/α-amination and horner-wadsworth-emmons olefination of aldehydes
Jha, Vishwajeet,Kondekar, Nagendra B.,Kumar, Pradeep
supporting information; experimental part, p. 2762 - 2765 (2010/08/19)
(Figure presented) A novel and general method for asymmetric synthesis of both syn/anti-1,3-amino alcohols is described. The method uses proline-catalyzed sequential α-aminoxylation/ α-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes as the key step. By using this method, a short synthesis of a bioactive molecule, (R)-1-((S)-1-methylpyrrolidin-2-yl)-5- phenylpentan-2-ol, is also accomplished.
Iterative approach to enantiopure synlanti-1,3-polyols via proline-catalyzed sequential a-aminoxylation and horner-wadsworth-emmons olefination of aldehvdes
Kondekar, Nagendra B.,Kumar, Pradeep
supporting information; experimental part, p. 2611 - 2614 (2009/10/23)
Iterative use of proline-catalyzed tandem α-aminoxylation and HWE olefination of aldehydes provided a simple access to 1,3-polyols. The feasibility of this approach is initially studied to synthesize syn- and anti-1,3-diols and is further extended to a syn/syn-1,3,5-triol at a useful level of asymmetric induction and yield. Its usage is illustrated by the short synthesis of a hydroxylactone pheromone component, (2S,3S)-2- hydroxyhexylcyclopentanone.
A short synthesis of (+)-harzialactone A and (R)-(+)-4-hexanolide via proline-catalyzed sequential α-aminooxylation and Horner-Wadsworth-Emmons olefination of aldehydes
Kotkar, Shriram P.,Suryavanshi, Gurunath S.,Sudalai, Arumugam
, p. 1795 - 1798 (2008/02/11)
An efficient and short enantioselective synthesis of the antitumor marine metabolite, (+)-harzialactone A 1 and pheromone, (R)-(+)-4-hexanolide 2 using l-proline-catalyzed sequential α-aminooxylation and Horner-Wadsworth-Emmons olefination of the respecti
