955978-74-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-1H-indole-2-carbonitrile is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-Bromo-1H-indole-2-carbonitrile is used as a building block in the production of agrochemicals, such as pesticides and herbicides. Its versatility enables the creation of new compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Chemical Industry:
4-Bromo-1H-indole-2-carbonitrile is used as a versatile intermediate in organic synthesis, particularly in the preparation of heterocyclic compounds. Its unique properties make it a valuable component in the synthesis of various chemical compounds with diverse applications.
Used in Research and Development:
4-Bromo-1H-indole-2-carbonitrile is used as a research compound for exploring its potential applications in various fields. Its unique structure and reactivity make it an interesting candidate for the development of new synthetic routes and the discovery of novel compounds with potential applications in various industries.

InChI:InChI=1/C9H5BrN2/c10-8-2-1-3-9-7(8)4-6(5-11)12-9/h1-4,12H

Upstream product

• 16732-64-2 4-bromo-1H-indole-2-carboxylic acid 
• 955978-73-1 4-bromo-1H-indole-2-carboxamide 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

2-MORPHOLIN-4-YL-PYRIMIDINES AS PI3K INHIBITORS

The invention provides compounds which are pyrimidines of formula (I) wherein R1 is a group -NR-(CHR)m-X; R2 is a substituted indolyl group; R is H or C1-C6 alkyl; m is 1, 2, 3 or 4; and X is a pyridyl ring; and the pharmaceutically acceptable salts thereof. These compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (Ia) or (Ib): wherein R1, R2, R3, are as defined in the claims.