955978-76-4

Basic information

• Product Name: N-(3-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide
• Synonyms: N-(3-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide
• CAS NO: 955978-76-4
• Molecular Weight: 282.06
• Mol File: 955978-76-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide(955978-76-4)
• EPA Substance Registry System: N-(3-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide(955978-76-4)

Safety Data

• Hazardous Substances Data: 955978-76-4(Hazardous Substances Data)

Upstream product

• 55289-36-6 3-bromo-2-methylaniline 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 955978-77-5 N-[3-bromo-2-(bromomethyl)phenyl]-2,2,2-trifluoroacetamide 
• 955978-75-3 4-bromo-2-(trifluoromethyl)-1H-indole 

Relevant articles and documents

INDOLE AND BENZIMIDAZOLE DERIVATIVES AS DUAL 5-HT2A AND 5-HT6 RECEPTOR ANTAGONISTS

The invention relates to new 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-indoles and 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-benzimidazoles represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of Alzheimer's disease, Parkinson's disease, Levy body dementia, dementia-related psychosis, schizophrenia, delusional syndromes and other psychotic conditions related and not related to taking psychoactive substances, depression, anxiety disorders of various aetiology, sleep disorders of various aetiology.

2-MORPHOLIN-4-YL-PYRIMIDINES AS PI3K INHIBITORS

The invention provides compounds which are pyrimidines of formula (I) wherein R1 is a group -NR-(CHR)m-X; R2 is a substituted indolyl group; R is H or C1-C6 alkyl; m is 1, 2, 3 or 4; and X is a pyridyl ring; and the pharmaceutically acceptable salts thereof. These compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (Ia) or (Ib): wherein R1, R2, R3, are as defined in the claims.