955999-09-4

Basic information

• Product Name: (carbamoyl-p-tolyl-methyl)-carbamic acid tert-butyl ester
• Synonyms: (carbamoyl-p-tolyl-methyl)-carbamic acid tert-butyl ester
• CAS NO: 955999-09-4
• Molecular Weight: 264.324
• Mol File: 955999-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (carbamoyl-p-tolyl-methyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (carbamoyl-p-tolyl-methyl)-carbamic acid tert-butyl ester(955999-09-4)
• EPA Substance Registry System: (carbamoyl-p-tolyl-methyl)-carbamic acid tert-butyl ester(955999-09-4)

Safety Data

• Hazardous Substances Data: 955999-09-4(Hazardous Substances Data)

Upstream product

• 13227-01-5 2-amino-2-(4-methylphenyl)acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 541-41-3 chloroformic acid ethyl ester 
• 28044-77-1 [(tert-butoxycarbonyl)amino](4-methylphenyl)acetic acid 

Downstream Products

• 955999-23-2 [(2H-tetrazol-5-yl)-p-tolyl-methyl]-carbamic acid tert-butyl ester 
• 956004-58-3 C-(2H-tetrazol-5-yl)-C-p-tolyl-methylamine 
• 774225-33-1 N-Boc-amino-(4'-methylphenyl)acetonitrile 

Relevant articles and documents

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure

Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2 A, and confirmed the design.