956-92-3

Usage

Uses

Used in Pharmaceutical Industry:
Clonitazene is used as an analgesic agent for the management of moderate to severe pain. Its potent analgesic effects and shorter duration of action make it a potential alternative to other opioid drugs like morphine.
Used in Research:
Clonitazene is used for research purposes to study the effects and mechanisms of action of synthetic opioids. It can help in understanding the potential therapeutic applications and risks associated with the use of such drugs.
Note: Clonitazene is a controlled substance in many countries due to its potential for abuse and dependence. It is not approved for medical use.

Upstream product

• 106-39-8 bromochlorobenzene 
• 136918-14-4 phthalimide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 55275-44-0 4'-chloro-o-benzoylbenzoic acid chloride 

Downstream Products

• 1610474-65-1 C₂₈H₁₈ClNO 
• 131-09-9 2-chloroanthracene-9,10-dione 
• 38046-68-3 3-(4-chlorophenyl)benzo[c]isoxazole 

Relevant academic research and scientific papers

Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid

The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities.

Ir(I)-catalyzed enantioselective hydrogenolysis of 3-aryl-3-hydroxyisoindolin-1-ones

An enantioselective hydrogenolysis of 3-aryl-3-hydroxyisoindolin-1-ones under H2has been developed by using Ir(I)/(R)-MeO-Biphep complex as a catalyst. Cyclic diaryl methylamides were obtained in moderate to excellent yields and up to 92%?ee.

Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

The rhodium(III)-catalyzed redox-neutral coupling reaction of N-acyl ketimines generated in situ from 3-hydroxyisoindolinones with various activated olefins is described. This approach leads to the synthesis of bioactive spiroisoindolinone derivatives in

Chiral phosphoric acid catalyzed asymmetric hydrogenolysis of racemic 3-aryl-3-hydroxyisoindolin-1-ones

The enantioselective hydrogenolysis of racemic 3-aryl-3-hydroxyisoindolin- 1-ones catalyzed by BINOL-derived chiral phosphoric acid with benzothiazoline as the hydride source is described. The corresponding cyclic diaryl methylamines are obtained in good to excellent yields and up to 91% enantioselectivities.

Hydroxorhodium/chiral diene complexes as effective catalysts for the asymmetric arylation of 3-aryl-3-hydroxyisoindolin-1-ones

Water is out, aryl is in! Asymmetric synthesis of isoindoline-1-ones bearing an α-triaryl-substituted stereogenic center was realized in the enantioselective addition of arylboroxines to 3-aryl-3-hydroxyisoindolin-1-ones in the presence of a hydroxorhodium/chiral diene catalyst, where cyclic N-carbonyl ketimines were generated in situ by dehydration. Copyright