95601-02-8Relevant academic research and scientific papers
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 62. REACTIONS OF METHYLENEBISPHOSPHONATE WITH α-NITROALKENES. A NOVEL SYNTHESIS OF ETHENYLIDENEBISPHOSPHONATES AND 2-ISOXAZOLINE-5,5-DIYLBISPHOSPHONATES
Yuan, Chengye,Li, Chaozhong
, p. 75 - 82 (2007/10/02)
Reaction of methylenebisphosphonate with α-nitroalkenes followed by addition of trimethylchlorosilane leads to the formation of ethenylidenebisphosphonates and trimethylsilyl nitronate in almost quantitative yield.These two products, upon prolonged reaction at ambient temperature, provide 2-isoxazoline-5,5-diylbisphosphonates via regioselective 1,3-dipolar cycloaddition in high yield.Key words: Methylenebisphosphonate; α-nitroalkenes; ethenylidenebisphosphonate; 2-isoxazoline-5,5-diylbisphosphonate; 1,3-dipolar cycloaddition.
