956016-89-0Relevant academic research and scientific papers
Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies
Mugnaini, Claudia,Rajamaki, Suvi,Tintori, Cristina,Corelli, Federico,Massa, Silvio,Witvrouw, Myriam,Debyser, Zeger,Veljkovic, Veljko,Botta, Maurizio
, p. 5370 - 5373 (2007)
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC50 = 12 μM.
