956018-45-4Relevant academic research and scientific papers
Design, synthesis and anticancer activity of 2-arylimidazo[1,2-a]pyridinyl-3-amines
Ansari, Arshad J.,Arora, Sahil,Dogra, Nilambra,Joshi, Gaurav,Kaur, Harsimrat,Kumar, Raj,Kumar, Santosh,Sawant, Devesh M.,Singh, Sandeep,Singh, Tashvinder,Yadav, Umesh Prasad
, (2021/11/19)
A series of imido-heterocycle compounds were designed, synthesized, characterized, and evaluated for the anticancer potential using breast (MCF-7 and MDA-MB-231), pancreatic (PANC-1), and colon (HCT-116 and HT-29) cancer cell lines and normal cells, while
Imidazolopiperazines: Hit to lead optimization of new antimalarial agents
Wu, Tao,Nagle, Advait,Kuhen, Kelli,Gagaring, Kerstin,Borboa, Rachel,Francek, Caroline,Chen, Zhong,Plouffe, David,Goh, Anne,Lakshminarayana, Suresh B.,Wu, Jeanette,Ang, Hui Qing,Zeng, Peiting,Kang, Min Low,Tan, William,Tan, Maria,Ye, Nicole,Lin, Xuena,Caldwell, Christopher,Ek, Jared,Skolnik, Suzanne,Liu, Fenghua,Wang, Jianling,Chang, Jonathan,Li, Chun,Hollenbeck, Thomas,Tuntland, Tove,Isbell, John,Fischli, Christoph,Brun, Reto,Rottmann, Matthias,Dartois, Veronique,Keller, Thomas,Diagana, Thierry,Winzeler, Elizabeth,Glynne, Richard,Tully, David C.,Chatterjee, Arnab K.
experimental part, p. 5116 - 5130 (2011/09/16)
Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimi
