95602-15-6

Upstream product

• 126-81-8 dimedone 
• 6315-89-5 3,4-dimethoxyaniline 

Downstream Products

• 95602-19-0 5,5-Dimethyl-3-[3,4,4-trimethoxy-cyclohexa-2,5-dien-(E)-ylideneamino]-cyclohex-2-enone 
• 1427455-33-1 dimethyl 4,4-dimethyl-1-oxo-2-(p-tolyl)-2,4,7,8-tetrahydro-1H-azepino[3,2,1-de]pyrrolo[4,3,2-mn]acridine-6,7-dicarboxylate 
• 1607027-25-7 C₃₉H₃₇N₃O₄ 
• 1531586-87-4 5-(3,4-dimethoxyphenyl)-11-(4-methoxybenzoyl)-3,3-dimethyl-2,3,4,5-tetrahydro-1H-indolo[2,3-b]quinolin-1-one 
• 1414774-52-9 N-carbamoyl-1-(3,4-dimethoxyphenyl)-3-hydroxy-6,6-dimethyl-2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-indole-3-carboxamide 

Relevant academic research and scientific papers

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.

OXIDATIVE CYCLIZATION OF 3-ANILINO-CYCLOHEX-2-ENONES TO TETRAHYDROCARBAZOLES

3-Anilino-cyclohex-2-enones 1a-1c are prepared from anilines and 5,5-dimethyl-1,3-cyclohexanedione.Anodic oxidation of 1a affords the p-benzoquinone monoimine dimethyl acetal 4, that is cyclized with CF3CO2H to the tetrahydrocarbazole 6.Lead tetraacetate

ANODIC INTRAMOLECULAR ARYLATION OF ENAMINONES

N-Benzyl- and β-phenethyl-enaminones are cyclized at the anode to isoquinolines and benzazepines.