956024-14-9Relevant articles and documents
First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-α production
Ye, Yue Qi,Koshino, Hiroyuki,Onose, Jun-Ichi,Yoshikawa, Kunie,Abe, Naoki,Takahashi, Shunya
, p. 4131 - 4134 (2008/02/13)
Vialinin A, a powerful inhibitor (IC50 90 pM) of TNF-α production, was synthesized from sesamol in 11 steps with 28% overall yield. The key reactions include a double Suzuki coupling of electron-rich aryl triflate with phenylboronic acid and an