956103-76-7

Usage

Uses

Used in Medical Imaging Industry:
Florbetapir F 18 is used as a PET imaging ligand for the detection and assessment of amyloid plaques in the brain. The presence of these plaques is a key indicator of Alzheimer's disease, and early diagnosis is crucial for effective treatment and management of the condition.
Florbetapir F 18 is used as a diagnostic tool for identifying the presence of amyloid aggregation in the brain, which is associated with Alzheimer's disease. This allows healthcare professionals to make more accurate diagnoses and develop appropriate treatment plans for patients showing signs of cognitive decline or dementia.

Upstream product

• 1205550-99-7 (E)-2-[2-[2-[5-[4-[tert-butoxycarbonyl[methyl]amino]styryl]pyridine-2-yloxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Preparation and stability of ethanol-free solution of [18F] florbetapir ([18F]AV-45) for positron emission tomography amyloid imaging

We have developed an ethanol-free formulation method of [ 18F]florbetapir ([18F]AV-45) using a commercially available automated JFE multi-purpose synthesizer. We have also evaluated the radiochemical stability in an ethanol-free solution of [ 18F]AV-45 under visible light irradiation and dark conditions by comparison with a conventional 10% ethanol solution of [18F]AV-45. [18F]AV-45 was obtained with a radiochemical yield of 55.1 ± 2.2% (decay-corrected to end of bombardment), specific activity of 591.6 ± 90.3 GBq/μmol and radiochemical purity of >99% within a total synthesis time of about 73 min. The radiochemical purity of [ 18F]AV-45 formulated by dissolving the ethanol-free solution was found to decrease as a function of the period of exposure to visible light. In contrast, the visible light photolysis could be suppressed by adding 10% ethanol to the formulation or by avoiding exposure to visible light. In the radiosynthesis of [18F]AV-45 formulated by dissolving the ethanol-free solution, [18F]AV-45 could be obtained with high radiochemical purity and high stability by avoiding exposure to visible light. Copyright

An improved preparation of [18F]AV-45 by simplified solid-phase extraction purification

Amyvid (florbetapir f18, [18F]AV-45, [18F]5) was the first FDA-approved positron emission tomography imaging agent targeting β-amyloid (Aβ) plaques for assisting the diagnosis of Alzheimer disease. This work aimed to improve the [su

A New Highly Deuterated [18F]AV-45, [18F]D15FSP, for Imaging β-Amyloid Plaques in the Brain

[18F]AV-45 (florbetapir f18, Amyvid) is an FDA-approved PET imaging agent targeting Aβ plaques in the brain for diagnosis of Alzheimer's disease (AD). Its metabolites led to a high background in the brain and large bone uptake of [18F]F-, produced from dealkylation of the PEG chain. To slow down the in vivo metabolism, we report the design, synthesis, and evaluation of a highly deuterated derivative, [18F]D15FSP, and compared it with N-methyl-deuterated [18F]D3FSP and nondeuterated [18F]AV-45. D15FSP displayed excellent binding affinity (Ki = 7.52 nM) to Aβ aggregates. In vitro autoradiography of [18F]D15FSP, [18F]D3FSP, and [18F]AV-45 showed excellent binding to Aβ plaques in human AD brain sections. Biodistribution studies displayed lower bone uptake at 120 min for [18F]D15FSP compared to that for [18F]D3FSP and [18F]AV-45 (1.44 vs 4.23 and 4.03%ID/g, respectively). As the highly deuterated [18F]D15FSP displayed excellent Aβ binding affinity, high initial brain penetration, and lower bone retention, it might be suitable for PET imaging in detecting Aβ plaques.

F-18 GRK amyloidosis · · labeled ligand of manufacturing method (by machine translation)

PROBLEM TO BE SOLVED: F-18 sign of tracer can be firmly and safely. SOLUTION: having a halogen or sulfonyloxycarbonyl (aryl/heteroarylacetic vinyl)-Pyridylphenylmethylsulfone F-18 amine derivative fluorinating agent by radioactive labeling, pegylation eq. 1 is represented by [F-18] fluoro (aryl/heteroarylacetic vinyl)-Pyridylphenylmethylsulfone amine derivative. The X CH or N, n the 1-6. Selected drawing: no (by machine translation)

METHOD FOR PREPARING FLUORINE-18 ELUENT WITH ADJUSTED PH, AND METHOD FOR LABELLING FLUORINE-18 USING SAME

The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [18F]fluoride in a method for preparing an organic [18F]fluoro compound by reacting an a