956109-57-2

Basic information

• Product Name: (S)-3-aMino-1-Methylazepan-2-one hydrochloride
• Synonyms: (S)-3-aMino-1-Methylazepan-2-one hydrochloride;(3S)-3-Amino-1-MethylazepaN-2-One,Hydrochloride
• CAS NO: 956109-57-2
• Molecular Formula: C₇H₁₄N₂O*ClH
• Molecular Weight: 178.6598
• Mol File: 956109-57-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-3-aMino-1-Methylazepan-2-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-aMino-1-Methylazepan-2-one hydrochloride(956109-57-2)
• EPA Substance Registry System: (S)-3-aMino-1-Methylazepan-2-one hydrochloride(956109-57-2)

Safety Data

• Hazardous Substances Data: 956109-57-2(Hazardous Substances Data)

Usage

General Description

(S)-3-aMino-1-Methylazepan-2-one hydrochloride is a chemical compound that belongs to the class of Azepanes. It is a hydrochloride salt form of (S)-3-aMino-1-Methylazepan-2-one, which is a chiral building block used in the synthesis of various pharmaceuticals and chemical intermediates. (S)-3-aMino-1-Methylazepan-2-one hydrochloride is commonly used as a reactant in organic synthesis, particularly in the preparation of chiral compounds. It has also been studied for its potential use in the treatment of neurological disorders and as an analgesic. As a hydrochloride salt, it is more stable and soluble in water, making it easier to handle and utilize in various chemical reactions and applications.

Upstream product

• 26081-03-8 (S)-3-aminocaprolactam hydrochloride 
• 135582-97-7 (S)-2-(1-methyl-2-oxoazepan-3-yl)isoindoline-1,3-dione 
• 61071-66-7 2-[(3S)-2-oxoazepan-3-yl]isoindoline-1,3-dione 
• 1152110-40-1 1,1-dimethylethyl ((3S)-1-methyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)carbamate 
• 643043-53-2 (S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate 

Relevant articles and documents

Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates

Lomibuvir (1) is a non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase with demonstrated clinical efficacy. Further development efforts within this class of inhibitor focused on improving the antiviral activity and physicochemical and pharmacokinetic properties. Recently, we reported the development of this series, leading to compound 2, a molecule with comparable potency and an improved physicochemical profile relative to 1. Further exploration of the amino amide-derived side chain led to a series of lactam derivatives, inspired by the X-ray crystal structure of related thiophene carboxylate inhibitors. This series, exemplified by 12f, provided 3-5-fold improvement in potency against HCV replication, as measured by replicon assays. The synthesis, structure-activity relationships, in vitro ADME characterization, and in vivo evaluation of this novel series are discussed.

P38 INHIBITORS AND METHODS OF USE THEREOF

Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.