956111-99-2

Upstream product

• 956111-98-1 C₁₉H₂₆N₂O₆ 
• 1095973-66-2 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(phenylmethoxy)ethyl]-2-(4S)-oxazoline methyl ester 
• 956111-97-0 C₁₉H₂₈N₂O₇ 
• 817625-25-5 (S)-2-((S)-3-benzyloxy-2-tert-butoxycarbonylaminopropionylamino)-3-hydroxypropionic acid methyl ester 
• 23680-31-1 BOC-O-benzyl-L-serine 

Downstream Products

• 1355992-83-4 C₅₈H₆₀N₈O₁₅ 
• 1355992-84-5 C₅₂H₄₈N₈O₁₂ 
• 1355992-85-6 C₅₂H₄₈N₈O₁₂ 
• 301662-30-6 2-((S)-2-Benzyloxy-1-{[2-((S)-2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester 
• 956111-91-4 C₂₉H₃₃N₅O₉ 
• 956111-89-0 C₂₉H₃₇N₅O₁₀ 
• 956111-88-9 C₃₈H₅₇N₅O₁₀Si 
• 1111629-72-1 C₂₇H₂₉N₅O₉ 
• 1111629-64-1 C₂₉H₃₅N₅O₉ 
• 1111629-70-9 C₂₇H₃₃N₅O₁₀ 
• 301661-90-5 2-((S)-1-Amino-2-benzyloxy-ethyl)-oxazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A convenient method for synthesis of tetraoxazole peptide macrocycles

G-quadruplex DNA plays important regulatory roles in the maintenance of telomere length and transcriptions inhibition of such oncogenes as c-myc, and thus has become an attractive target for the development of anti-cancer therapeutic agents. Poly-oxazole macrocycles are a promising new class of G-quadruplex binding ligands. Herein is described the synthesis of a tetraoxazole peptide macrocycle and an epimerization product. The synthetic unit was prepared by cyclization-oxidation of a diserine with one hydroxyl protected. Two-cycle coupling of the unit gave a linear tetraoxazole amide. The targeted molecule and the epimerization product were obtained after macrocyclization of the linear precursor and following removal of the protecting benzyl groups. With structural similarities to the most potent G-quadruplex stabilizer telomestatin, these two molecules might potentially be used to probe the biological significance of G-quadruplex' in vivo.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n' and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.

Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin

A convergent, complementary, synthetic approach to the contiguously linked tris-oxazole units 10, 11 and 12 in telomestatin (1) and YM-216391 (2) is described. The route involves coupling reactions between oxazole 4-carboxylic acids, viz16a, 16c, 16d and

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.