956112-10-0Relevant articles and documents
Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles
Minhas, Gurpreet Singh,Pilch, Daniel S.,Kerrigan, John E.,LaVoie, Edmond J.,Rice, Joseph E.
, p. 3891 - 3895 (2006)
The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxida
THERAPEUTIC COMPOUNDS
-
Page/Page column 37-38, (2009/07/03)
The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.
THERAPEUTIC COMPOUNDS
-
Page/Page column 60-61, (2008/06/13)
The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.