95614-38-3Relevant academic research and scientific papers
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Sheppeck II, James E.,Gilmore, John L.,Tebben, Andrew,Xue, Chu-Biao,Liu, Rui-Qin,Decicco, Carl P.,Duan, James J.-W.
, p. 2769 - 2774 (2008/02/05)
We have discovered selective and potent inhibitors of TACE that replace the common hydroxamate zinc binding group with a hydantoin, triazolone, and imidazolone heterocycle. These novel heterocyclic inhibitors of a zinc metalloprotease were designed using
