956143-80-9

Upstream product

• 956143-54-7 methyl 2-((2S,3S,4S,6R)-4-((2S,3R,4S,5R)-3-benzyloxy-4,5-dimethoxy-tetrahydro-2H-pyran-2-yloxy)-6-((S)-2-(4-methoxybenzyloxy)-2-((1R,2R)-2-methylcyclopropyl)ethyl)-3-methyl-tetrahydro-2H-pyran-2-yl)acetate 
• 956143-49-0 (2R,3R,4S,5R)-3-benzyloxy-4,5-dimethoxy-tetrahydro-2H-pyran-2-yl 2,2,2-trichloroacetimidate 
• 106-95-6 allyl bromide 

Downstream Products

• 956143-56-9 allyl 2-((2S,3S,4S,6R)-4-((2S,3R,4S,5R)-3-benzyloxy-4,5-dimethoxy-tetrahydro-2H-pyran-2-yloxy)-6-((S)-2-hydroxy-2-((1R,2R)-2-methylcyclopropyl)ethyl)-3-methyl-tetrahydro-2H-pyran-2-yl)acetate 
• 956143-62-7 C₆₁H₉₀O₁₈ 
• 956143-84-3 C₅₃H₈₂O₁₇ 
• 956143-86-5 C₅₀H₇₆O₁₆ 

Relevant academic research and scientific papers

Enantioselective total synthesis of (-)-Clavosolide A and B

Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The relative and absolute stereochemistries of the natural products were confirmed unambiguously by comparing the optical rotation values and 1H and 13C NMR spectra of them.

Enantioselective total synthesis of (-)-clavosolide B

Enantioselective synthesis of 2, a revised structure for (-)-clavosolide B, was accomplished by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization re