95617-55-3

Basic information

• Product Name: Z-D-Ala-gPhe-Gly-COH
• Synonyms: Z-D-Ala-gPhe-Gly-COH
• CAS NO: 95617-55-3
• Molecular Weight: 426.472
• Mol File: 95617-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-D-Ala-gPhe-Gly-COH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-D-Ala-gPhe-Gly-COH(95617-55-3)
• EPA Substance Registry System: Z-D-Ala-gPhe-Gly-COH(95617-55-3)

Safety Data

• Hazardous Substances Data: 95617-55-3(Hazardous Substances Data)

Upstream product

• 2491-15-8 formylglycine 
• 95617-40-6 Z-D-Ala-gPhe-H*HCl 

Downstream Products

• 95617-95-1 H-D-Ala-gPhe-Gly-COH acetate 

Relevant articles and documents

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.