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"Z-D-Ala-gPhe-Gly-CO-Bzl" is a synthetic peptide compound, where "Z" stands for a carbobenzoxy (Cbz) protecting group, "D-Ala" represents D-alanine, "gPhe" is glycine-modified phenylalanine, "Gly" is glycine, and "CO-Bzl" indicates a benzyl ester group. Z-D-Ala-gPhe-Gly-CO-Bzl is a pentapeptide, meaning it consists of five amino acid residues. It is often used in pharmaceutical research, particularly in the study of peptide synthesis and as a building block for more complex peptide structures. The protecting groups are crucial for preventing unwanted side reactions during peptide synthesis, and they are removed at specific stages of the process to yield the desired peptide. The benzyl ester group is used to facilitate the purification and isolation of the peptide. Z-D-Ala-gPhe-Gly-CO-Bzl is a precursor in the synthesis of certain peptide drugs and can be found in research related to antibiotics, opioids, and other bioactive peptides.

95617-56-4

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95617-56-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 95617-56-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,6,1 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 95617-56:
(7*9)+(6*5)+(5*6)+(4*1)+(3*7)+(2*5)+(1*6)=164
164 % 10 = 4
So 95617-56-4 is a valid CAS Registry Number.

95617-56-4Relevant academic research and scientific papers

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

Salvadori, Severo,Marastoni, Mauro,Balboni, Gianfranco,Sarto, Gian Pietro,Tomatis, Roberto

, p. 769 - 774 (2007/10/02)

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.

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