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Z-D-Ala-gPhe-Gly-CO-Ad is a synthetic peptide consisting of five amino acids: Z-D-alanine, glycine, phenylalanine, and two additional amino acids, with a terminal adipic acid (Ad) group. This specific sequence is designed to mimic the structure of certain natural peptides, potentially for research or therapeutic purposes. The "Z" prefix indicates that the peptide is protected with a benzyloxycarbonyl (Cbz) group, which is a common strategy in peptide synthesis to prevent unwanted side reactions. The "D" prefix before alanine signifies that it is the D-isomer of alanine, which is less common in naturally occurring proteins but can be used in synthetic compounds for specific properties. The "g" in glycine could refer to a gamma linkage or a modified glycine. This peptide may be used in various applications, such as studying peptide-protein interactions, drug development, or as a component in chemical biology research.

95617-58-6

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95617-58-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 95617-58-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,6,1 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 95617-58:
(7*9)+(6*5)+(5*6)+(4*1)+(3*7)+(2*5)+(1*8)=166
166 % 10 = 6
So 95617-58-6 is a valid CAS Registry Number.

95617-58-6Relevant academic research and scientific papers

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

Salvadori, Severo,Marastoni, Mauro,Balboni, Gianfranco,Sarto, Gian Pietro,Tomatis, Roberto

, p. 769 - 774 (2007/10/02)

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.

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