95617-70-2

Usage

Uses

Used in Pharmaceutical Industry:
D-Alaninamide, L-tyrosyl-N-[1-[(carboxyacetyl)amino]-2-phenylethyl]-, (S)is used as a potential drug candidate for the development of new medications due to its unique structure and potential biological activity.
Used in Biotechnology Industry:
D-Alaninamide, L-tyrosyl-N-[1-[(carboxyacetyl)amino]-2-phenylethyl]-, (S)is used as a research target for understanding its properties and exploring its potential applications in various biotechnological processes.

Upstream product

• 95617-42-8 Boc-Tyr-D-Ala-gPhe-mGly-OEt 
• 20866-56-2 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tyrosinate 
• 95617-43-9 Boc-Tyr-D-Ala-gPhe-mGly-OH 

Relevant academic research and scientific papers

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.