956226-92-9

Upstream product

• 956226-91-8 (2R,4R,5R)-1-aza-2-(tert-butyl)-6-hydroxy-5-methoxycarbonyl-4-methyl-8-oxo-7-phenyl-3-oxabicyclo[3.3.0]oct-6-ene 
• 956227-04-6 (2R,4S,5R)-2-(tert-butyl)-3-(2-phenylacetyl)-5-methyl-4-methoxycarbonyloxazolidine 

Downstream Products

• 956226-99-6 (2R,1'R)-3-hydroxy-2-(1'-hydroxyethyl)-4-phenyl-1H-pyrrol-2(5H)-one 

Relevant academic research and scientific papers

Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.