956299-75-5Relevant academic research and scientific papers
Synthesis of bistetrahydroquinolines as potential anticholinesterasic agents by double diels-alder reactions
Duarte, Yorley,Gutierrez, Margarita,Astudillo, Luis,Alzate-Morales, Jans,Valdes, Natalia
, p. 12951 - 12965 (2013)
The tetrahydroquinoline ring system is a unit found in many biologically active natural products and pharmacologically relevant therapeutic agents. A new series of bistetrahydroquinolines (bis-THQs) was synthesized using imino Diels-Alder reactions betwee
Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4
Mooring, Suazette Reid,Gaines, Theresa,Liang, Zhongxing,Shim, Hyunsuk
, p. 149 - 153 (2014/07/07)
A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory diseases, and cancer metastasis. The compounds were tested for activity using an affinity binding assay and an assay that tests the ability to inhibit cell invasion. Two hit compounds (2b and 2j) have been identified for further evaluation that inhibit cell invasion by at least 50% and have an effective concentration of less than 100 nm in the binding affinity assay. The structures of the synthesized compounds were confirmed by spectral data.
