956387-28-3Relevant articles and documents
Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness
Sumalekshmy,Henary, Maged M.,Siegel, Nisan,Lawson, PaDreyia V.,Wu, Yonggang,Schmidt, Karin,Bredas, Jean-Luc,Perry, Joseph W.,Fahrni, Christoph J.
, p. 11888 - 11889 (2008/03/27)
To develop metal-responsive fluorescence probes with optimized nonlinear optical properties for two-photon excitation fluorescence microscopy (TPEM), we investigated the utility of donor-acceptor architectures where the metal-ion coordinates to the acceptor rather than donor site of the fluorophore. Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (δ) and fluorescence brightness (ηδ). The fluorophore showed also a strong shift of the emission peak upon saturation with Zn(II), rendering the proposed approach suitable for two-photon excited emission ratiometric sensing. Copyright