95646-80-3

Basic information

• Product Name: Carbamic acid, [2-oxo-2-[[[(phenylacetyl)amino]methyl]amino]-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-
• CAS NO: 95646-80-3
• Molecular Formula: C26H27N3O4
• Molecular Weight: 445.518
• Mol File: 95646-80-3.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-oxo-2-[[[(phenylacetyl)amino]methyl]amino]-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-oxo-2-[[[(phenylacetyl)amino]methyl]amino]-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(95646-80-3)
• EPA Substance Registry System: Carbamic acid, [2-oxo-2-[[[(phenylacetyl)amino]methyl]amino]-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-(95646-80-3)

Safety Data

• Hazardous Substances Data: 95646-80-3(Hazardous Substances Data)

Upstream product

• 23776-85-4 N-(phenylacetyl)oxysuccinimide 
• 95617-47-3 [1-S-(aminomethyl-carbamoyl)-2-phenylethyl]carbamic acid benzyl ester hydrochloride 

Downstream Products

• 95646-84-7 H-Phe-gGly-COBzl acetate 

Relevant articles and documents

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.