95648-08-1Relevant academic research and scientific papers
Deconjugative Alkylation of α,β-Acetylenic Esters by Electrogenerated Base
Tokuda, Masao,Nishio, Osamu
, p. 1592 - 1596 (1985)
Electrolysis of ethyl propiolate (1) and an excess of methyl iodide at a platinum cathode in hexamethylphosphoric triamide (HMPA) or N,N-dimethylformamide (DMF) solution containing tetra-n-butylammonium salt gave the acetylenic esters 2, 3, and 4.Similar electrochemical reactions of α,β-acetylenic esters 2, 5, and 9 with methyl iodide took place in good yields to give the corresponding α,α-dimethyl-β,γ-acetylenic esters 3 and 4, 4, and 10, respectively.Electrochemical reactions of 5 with ethyl, butyl, and allyl iodides also gave α,α-dialkyl β,γ-acetylenic esters 6, 7, and 8, respectively.These facile deconjugative alkylations appeared to take place by the action of the electrogenerated base (EGB) which was formed by the electrochemical reduction of alkyl iodides.Alkyl iodides worked as both a probasic compound of the EGB and as an electrophile.Reaction pathways of the present deconjugative alkylations are also discussed.
PYRAZINE SUBSTITUTED IMIDAZOLE DERIVATIVE
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Paragraph 0040; 0041, (2016/10/09)
PROBLEM TO BE SOLVED: To provide a novel pyrazine substituted imidazole derivative that is useful as a therapeutic agent or preventive agent for diseases associated with URAT1, such as gout, hyperuricemia, hypertension, kidney diseases such as interstitia
Infrared spectroscopy and ab initio computation in conformer determination of keto ester and diketo triphenylphosphonium ylides
Bunton, Clifford A.,Casta?eda, Fernando
experimental part, p. 132 - 136 (2010/03/26)
For stabilized triphenylphosphonium keto ester ylides acyl stretching frequencies of the anti ester group from HF/6-31G(d) calculations fit experimental values with Scale Factor, SF = 0.866, as estimated earlier for the diester ylides, but Scale Factor =
