956484-64-3Relevant articles and documents
Fluorous-tagged carbamates for the Pd-catalyzed amination of aryl halides
Trabanco, Andres A.,Vega, Juan A.,Fernandez, M. Alejandro
, p. 8146 - 8148 (2008/02/12)
(Chemical Equation Presented) A novel fluorous-tagged ammonia surrogate has been synthesized and its application to the synthesis of anilines by Buchwald-Hartwig palladium-catalyzed amidation-hydrolysis protocol is described. Primary anilines were obtained in moderate to good yields after a sequence of two reaction steps involving fluorous separation techniques for their purification. Preliminary results indicate that N-substituted anilines can also be obtained using just N-substituted-FBoc carbamates as the nitrogen source.