956484-95-0Relevant academic research and scientific papers
Configuration of the 5′-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides
Seth, Punit P.,Allerson, Charles R.,Siwkowski, Andrew,Vasquez, Guillermo,Berdeja, Andres,Migawa, Michael T.,Gaus, Hans,Prakash, Thazha P.,Bhat, Balkrishen,Swayze, Eric E.
experimental part, p. 8309 - 8318 (2011/02/23)
As part of a program aimed at exploring the structure- activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs), we report the synthesis and biophysical and biological properties of R- and S-5′-Me LNA modifie
