956485-60-2 Usage
General Description
6-Bromo-3-iodo-1H-pyrrolo[3,2-b]pyridine is a chemical compound with the molecular formula C8H5BrIN2. It is a heterocyclic compound with a fused pyrrolopyridine ring system. This chemical is mainly used in scientific research as a building block in the synthesis of various organic compounds. Its unique structure and reactivity make it valuable for drug discovery and development. It has also been studied for its potential pharmacological properties and has shown promise as a potential drug candidate for the treatment of certain diseases. Due to its specialized uses and applications, it is primarily utilized in laboratory settings and is not commonly found in consumer products or industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 956485-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,6,4,8 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 956485-60:
(8*9)+(7*5)+(6*6)+(5*4)+(4*8)+(3*5)+(2*6)+(1*0)=222
222 % 10 = 2
So 956485-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrIN2/c8-4-1-6-7(11-2-4)5(9)3-10-6/h1-3,10H
956485-60-2Relevant articles and documents
A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase
Wouters, Randy,Tian, Junjun,Herdewijn, Piet,De Jonghe, Steven
, p. 237 - 254 (2019/01/08)
We recently reported the discovery of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity for GAK and demonstrating broad-spectrum antiviral activity. To come up with novel core structures that act as GAK inhibitors, a scaffold-hopping approach was applied starting from two different isothiazolo[4,3-b]pyridines. In total, 13 novel 5,6- and 6,6-fused bicyclic heteroaromatic scaffolds were synthesized. Four of them displayed GAK affinity with Kd values in the low micromolar range that can serve as chemical starting points for the discovery of GAK inhibitors based on a different scaffold.
