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956488-58-7

4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 956488-58-7 Structure

  • Basic information

    1. Product Name: 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine
    2. Synonyms: 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine
    3. CAS NO:956488-58-7
    4. Molecular Formula:
    5. Molecular Weight: 346.343
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 956488-58-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine(956488-58-7)
    11. EPA Substance Registry System: 4-(3-N-(tert-butoxycarbonyl)aminophenoxy)-3-nitropyridin-2-amine(956488-58-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 956488-58-7(Hazardous Substances Data)

956488-58-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 956488-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,6,4,8 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 956488-58:
(8*9)+(7*5)+(6*6)+(5*4)+(4*8)+(3*8)+(2*5)+(1*8)=237
237 % 10 = 7
So 956488-58-7 is a valid CAS Registry Number.

956488-58-7Relevant articles and documents

BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring

Nourry, Arnaud,Zambon, Alfonso,Davies, Lawrence,Niculescu-Duvaz, Ion,Dijkstra, Harmen P.,Ménard, Delphine,Gaulon, Catherine,Niculescu-Duvaz, Dan,Suijkerbuijk, Bart M. J. M.,Manne, Frank Friedlos Helen A.,Kirk, Ruth,Whittaker, Steven,Marais, Richard,Springer, Caroline J.

supporting information; experimental part, p. 1964 - 1978 (2010/08/05)

We recently reported on the development of a novel series of BRAF inhibitors based on a tripartite A-B-C system characterized by a para-substituted central aromatic core connected to an imidazo[4,5]pyridin-2-one scaffold and a substituted urea linker. Here, we present a new series of BRAF inhibitors in which the central phenyl ring connects to the hinge binder and substrate pocket of BRAF with a meta-substitution pattern. The optimization of this new scaffold led to the development of lownanomolar inhibitors that permits the use of a wider range of linkers and terminal C rings while enhancing the selectivity for the BRAF enzyme in comparison to the para series.

PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE

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Page/Page column 97, (2009/07/18)

The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.

IMIDAZO[4, 5-B]PYRIDIN-2-ONE AND OXAZOLO[4, 5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS

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Page/Page column 133-134, (2008/06/13)

The present invention pertains to certain imidazo[4,5-blpyridin-2-one and oxazolo[4,5 blpyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particular

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