95649-22-2

Upstream product

• 5873-90-5 methyl benzimidate hydrochloride 
• 95649-37-9 N'-hydroxy-1H-indole-3-carboximidamide 
• 95649-32-4 C₁₆H₁₃N₃O₂ 
• 19747-78-5 indole-3-carboxylic acid ethyl imido ester hydrochloride 
• 487-89-8 Indole-3-carboxaldehyde 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. 37. SYNTHESIS OF 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLES CONTAINING INDOLE RADICALS

The 1,3-dipolar cycloaddition of nitrile N-oxides to indole nitriles yields 3,5-disubstituted 1,2,4-oxadiazoles containing an indole radical at the 5 position.Condensation of amidoximes with indole iminoesters hydrochlorides yields 1,2,4-oxadiazoles havin