956578-85-1Relevant articles and documents
Synthesis of chlorogenic acid derivatives with promising antifungal activity
Ma, Chao-Mei,Kully, Maureen,Khan, Jehangir K.,Hattori, Masao,Daneshtalab, Mohsen
, p. 6830 - 6833 (2007)
Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.