956597-80-1Relevant academic research and scientific papers
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator
Zhang, Bo,Wang, Yan,Huang, Shenlong,Sun, Jiaqi,Wang, Min,Ma, Wenxiao,You, Yanbo,Wu, Ling,Hu, Jin,Song, Wei,Liu, Xudong,Li, Shengjie,Chen, Hua,Zhang, Guisheng,Zhang, Lihe,Zhou, Demin,Li, Lingjun,Zhang, Xuan
, p. 60 - 7,69 (2020/12/07)
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, which leads to worrisome side effects. Engineering CAR-T cells to be as tightly controllable as possible remains a topic of ongoing investigation. Here, we report a photoswitchable approach that uses a mediator for the at-will regulation of CAR-T cells. This mediator carries dual folate and fluorescein isothiocyanate moieties tethered by an ortho-nitrobenzyl ester photocleavable linker. CAR-T cells were shown to be highly cytotoxic to targeted cells only in the presence of the mediator and acted in a dose-dependent manner. The toxicity of CAR-T cells can be rapidly terminated by cleavage of the mediator, and the effects of CAR-T cells can be activated again by resupplementation with the mediator without compromising tumor therapy. The approach described here provides a direction for enhancing the controllability of CAR-T cells and can likely be applied in other immunotherapies.CAR-T is a powerful technology for cancer therapy, but is largely limited by inherent controllability issues. Zhang et al. developed an accurate controllable approach based on the bond-cleavage chemistry combined with universal anti-FITC CAR-T cells, allowing the regulation of CAR-T cells in a switchable manner.
Kojic acid–natural product conjugates as mushroom tyrosinase inhibitors
Ashooriha, Morteza,Emami, Saeed,Kardan, Mostafa,Khoshneviszadeh, Mahsima,Khoshneviszadeh, Mehdi,Rafiei, Alireza,Yazdian-Robati, Rezvan
, (2020/07/10)
As part of our effort to develop potential tyrosinase inhibitors, we have conjugated the well-known tyrosinase inhibitor kojic acid (KA) with several phenolic natural products such as umbelliferone, sesamol, thymol, carvacrol, eugenol, isoeugenol, vanilli
Bis-Organosilicon based receptor for detection of Hg2+ ions: Low detection limit and excellent selectivity
Chowdhary, Kavita,Mohit,Satija, Pinky,Sharma, Geetika,Shilpy,Singh, Akshpreet,Singh, Gurjaspreet,Singh, Jandeep,Singh, Jasbhinder
, (2020/08/03)
Mercury Contamination represents a major environmental and health concern for which new eco-friendly solutions are desired. Azide–alkyne cycloaddition and Claisen Schmidt reaction were attempted to trigger a flavanone based bis-siloxyl hybrid materials. T
For the control of the chimeric antigen receptor of the T cell activation/inhibit the connecting arm and its application (by machine translation)
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Paragraph 0020; 0031; 0036, (2019/01/23)
The invention discloses a method for control CAR - T/inhibit the activation of the link arm, and one end of the cells containing the target [...] molecule, the other at one end and can be specific CAR - T cell identified with biological orthogonality of the part, and the middle of the can be biological orthogonal fracture chemical group coupling. This invention can realize the CAR - T cell from active to a resting state fast and flexible conversion, to CAR - T cell inhibiting the systematic and high efficiency. Adjusting has reversibility, not damage or kill some CAR - T cell, can realize the CAR - T cell from active to close and then to activate the flexible change, the overall functions of the treatment is not affected. (by machine translation)
4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation
Kumar, Sumit,Saini, Anu,Gut, Jiri,Rosenthal, Philip J.,Raj, Raghu,Kumar, Vipan
, p. 993 - 1001 (2017/08/02)
1H-1,2,3-triazole linked 4-aminoquinoline-chalcone/-N-acetylpyrazoline conjugates were synthesized and evaluated against cultured chloroquine (CQ) resistant strain. Antiplasmodial activities of the synthesized conjugates revealed dependence of activity on
Synthesis of novel symmetrical 1,4-disubstituted 1,2,3-bistriazole derivatives via 'click chemistry' and their biological evaluation
Dü?dü, Esra,ünlüer, Dilek,?elik, Fatih,Sancak, Kemal,Karao?lu, ?engül Alpay,?zel, Arzu
, (2016/06/15)
A series of symmetric bis-1,2,3-triazole compounds 2-5(a-f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected
Water-Soluble molecularly imprinted nanoparticles (MINPs) with tailored, functionalized, modifiable binding pockets
Awino, Joseph K.,Zhao, Yan
supporting information, p. 655 - 661 (2015/08/04)
Construction of receptors with binding sites of specific size, shape, and functional groups is important to both chemistry and biology. Covalent imprinting of a photocleavable template within surface-core doubly cross-linked micelles yielded carboxylic acid-containing hydrophobic pockets within the water-soluble molecularly imprinted nanoparticles. The functionalized binding pockets were characterized by their binding of amine- and acid-functionalized guests under different pH values. The nanoparticles, on average, contained one binding site per particle and displayed highly selective binding among structural analogues. The binding sites could be modified further by covalent chemistry to modulate their binding properties.
Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells
Chen, Jinying,Ma, Liang,Zhang, Ronghong,Tang, Jie,Lai, Huijun,Wang, Jun,Wang, Guangcheng,Xu, Qinyuan,Chen, Tao,Peng, Fei,Qiu, Jingxiang,Liang, Xiaolin,Cao, Dong,Ran, Yan,Peng, Aihua,Wei, Yuquan,Chen, Lijuan
, p. 945 - 956 (2013/02/22)
A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin congeners were synthesized by employing click chemistry and further evaluated for their antitumor activity by MTT assay. Among them, six congeners (10, 11, 12, 13, 22, and 24) exhibited ap
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones
Hans, Renate H.,Guantai, Eric M.,Lategan, Carmen,Smith, Peter J.,Wan, Baojie,Franzblau, Scott G.,Gut, Jiri,Rosenthal, Philip J.,Chibale, Kelly
supporting information; experimental part, p. 942 - 944 (2010/06/22)
A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy
High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry
Tan, Lay Pheng,Wu, Hao,Yang, Peng-Yu,Kalesh, Karunakaran A.,Zhang, Xiaohua,Hu, Mingyu,Srinivasan, Rajavel,Yao, Shao Q.
supporting information; experimental part, p. 5102 - 5105 (2010/03/24)
A ～500-member library of bidentate inhibitors against protein tyrosine phosphatases (PTPs) was rapidly assembled using click chemistry. Subsequent high-throughput screening had led to the discovery of highly potent (K i as low as 150 nM) and se
