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956597-80-1

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956597-80-1 Usage

General Description

1-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one is an organic compound with the molecular formula C12H12O3. It is a ketone derivative with a methoxy group and a propynyl ether group attached to a phenyl ring. 1-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one is commonly used in organic synthesis and chemical research as a building block for more complex molecules. It has the potential to be used in pharmaceuticals and agrochemicals due to its versatile chemical structure. Additionally, it may also have applications in the field of materials science and as a reagent in organic chemistry reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 956597-80-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,6,5,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 956597-80:
(8*9)+(7*5)+(6*6)+(5*5)+(4*9)+(3*7)+(2*8)+(1*0)=241
241 % 10 = 1
So 956597-80-1 is a valid CAS Registry Number.

956597-80-1Relevant articles and documents

Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator

Zhang, Bo,Wang, Yan,Huang, Shenlong,Sun, Jiaqi,Wang, Min,Ma, Wenxiao,You, Yanbo,Wu, Ling,Hu, Jin,Song, Wei,Liu, Xudong,Li, Shengjie,Chen, Hua,Zhang, Guisheng,Zhang, Lihe,Zhou, Demin,Li, Lingjun,Zhang, Xuan

, p. 60 - 7,69 (2020/12/07)

Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, which leads to worrisome side effects. Engineering CAR-T cells to be as tightly controllable as possible remains a topic of ongoing investigation. Here, we report a photoswitchable approach that uses a mediator for the at-will regulation of CAR-T cells. This mediator carries dual folate and fluorescein isothiocyanate moieties tethered by an ortho-nitrobenzyl ester photocleavable linker. CAR-T cells were shown to be highly cytotoxic to targeted cells only in the presence of the mediator and acted in a dose-dependent manner. The toxicity of CAR-T cells can be rapidly terminated by cleavage of the mediator, and the effects of CAR-T cells can be activated again by resupplementation with the mediator without compromising tumor therapy. The approach described here provides a direction for enhancing the controllability of CAR-T cells and can likely be applied in other immunotherapies.CAR-T is a powerful technology for cancer therapy, but is largely limited by inherent controllability issues. Zhang et al. developed an accurate controllable approach based on the bond-cleavage chemistry combined with universal anti-FITC CAR-T cells, allowing the regulation of CAR-T cells in a switchable manner.

Bis-Organosilicon based receptor for detection of Hg2+ ions: Low detection limit and excellent selectivity

Chowdhary, Kavita,Mohit,Satija, Pinky,Sharma, Geetika,Shilpy,Singh, Akshpreet,Singh, Gurjaspreet,Singh, Jandeep,Singh, Jasbhinder

, (2020/08/03)

Mercury Contamination represents a major environmental and health concern for which new eco-friendly solutions are desired. Azide–alkyne cycloaddition and Claisen Schmidt reaction were attempted to trigger a flavanone based bis-siloxyl hybrid materials. T

4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation

Kumar, Sumit,Saini, Anu,Gut, Jiri,Rosenthal, Philip J.,Raj, Raghu,Kumar, Vipan

, p. 993 - 1001 (2017/08/02)

1H-1,2,3-triazole linked 4-aminoquinoline-chalcone/-N-acetylpyrazoline conjugates were synthesized and evaluated against cultured chloroquine (CQ) resistant strain. Antiplasmodial activities of the synthesized conjugates revealed dependence of activity on

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