956598-31-5Relevant academic research and scientific papers
Characteristics of the halogenation of 2-substituted 6-benzhydryl-4(3H)- pyrimidinones
Novakov,Orlinson,Nawrozkij
, p. 1233 - 1235 (2006)
The halogenation of 2-substituted 6-benzhydryl-4(3H)-pyrimidinones has been investigated. Bromination with Py?Br2 and iodination with I2 solution in alkali occurs exclusively at the CH hydrogen of the benzhydryl group. Springer Scien
Synthesis and studies of new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-ones as possible HIV-1 reverse transcriptase inhibitors
Valuev-Elliston,Ivanov,Orlinson,Gerasimov,Brunilina,Zakharova,Kochetkov,Novakov,Navrotskii
, p. 797 - 801 (2014/01/23)
Six new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin- 4(3H)-one derivatives were synthesized and studied for biological activity. The studies showed that the 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-one derivatives inhibited activity of the HIV-1 recombinant reverse transcriptase in the micromolar range of concentrations. The 6-[halo-(diphenyl)methyl]pyrimidin-4(3H) -one derivative showed no activity in the concentrations up to 200 μmol mL-1.
