956599-48-7Relevant academic research and scientific papers
Development of a multikilogram synthesis of a chiral epoxide precursor to a CCR1 antagonist. Use of in situ monitoring for informed optimisation via fragile intermediates
Ange, Debra,Booker, James E. M.,Pedge, Nicholas,Sinclair, Rhona,Sleigh, Chris,Stefinovic, Marijan,Vaz, Luis-Manuel,Way, Edward
scheme or table, p. 72 - 84 (2010/05/02)
The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranyl- methoxy)phenyl ester (2), utilising a SNAr coupling, the hydro- genation of a nitro moiety and the conversion of a chi
NOVEL PROCESS I
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Page/Page column 38, (2008/06/13)
The present invention relates to a novel process for the preparation of compounds of Formula (I) wherein X, Q, R1 and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents. The invention further relates to novel intermediates useful in the preparation of the therapeutic agents.
