95667-14-4Relevant academic research and scientific papers
Regiospecificity in Reactions of Metal Phenoxides. Synthesis of 2,2'-alkylidenebisphenols
Casiraghi, Giovanni,Casnati, Giuseppe,Pochini, Andrea,Ungaro, Rocco
, p. 805 - 808 (2007/10/02)
The reactions between aryloxymagnesium bromides (1) with linear aliphatic aldehydes (2) and their acetals (10) in aprotic solvents of variable donicity have been investigated.In benzene high ortho-regiospecificity is observed in all cases, although with the aldehyde (2) the yield of 2,2'-alkylidenebisphenols (5) is usually low because of the competing aldehyde self-condensation.This process is avoided using diethyl acetals as electrophilic reagents which give the products (5) in good yields.
