95669-47-9Relevant academic research and scientific papers
Synthesis and α2-Adrenoceptor Antagonist Activity of Some Disulfonamidobenzoquinolizines
Ward, Terence J.,Warrellow, Graham J.,Stirrup, John A.,Lattimer, Norman,Rhodes, Keith F.
, p. 179 - 182 (2007/10/02)
A series of disulfonamidobenzoquinolizines were synthesized and evaluated for their α2- and α1-adrenoceptor antagonist activity on the rat vas deferens and anococcygeus muscle, respectively.N-((2β,11bα)-1,3,4,6,7,11b-Hexahydro-2H-benzoquinolizin-2-yl)-N-ethyl>methanesulfonamide (4) and its N-ethyl>ethanesulfonamide (22), N-ethyl>ethanesulfonamide (27), and N-ethyl>-4-methylbenzenesulfonamide (30) analogues showed 400-fold or greater selectivity in favor of α2- over α1-adrenoceptor blockade.
