956699-43-7

Basic information

• Product Name: 1,3-dimethoxy-2-hexyl-5-methoxymethylbenzene
• Synonyms: 1,3-dimethoxy-2-hexyl-5-methoxymethylbenzene
• CAS NO: 956699-43-7
• Molecular Weight: 266.381
• Mol File: 956699-43-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-dimethoxy-2-hexyl-5-methoxymethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethoxy-2-hexyl-5-methoxymethylbenzene(956699-43-7)
• EPA Substance Registry System: 1,3-dimethoxy-2-hexyl-5-methoxymethylbenzene(956699-43-7)

Safety Data

• Hazardous Substances Data: 956699-43-7(Hazardous Substances Data)

Upstream product

• 111-25-1 1-bromo-hexane 
• 75921-68-5 1,2,3-trimethoxy-5-(methoxymethyl)benzene 

Downstream Products

• 41442-51-7 1,3-dimethoxy-2-hexyl-5-methylbenzene 

Relevant articles and documents

Ion pairing effects on the regioselectivity of arylic versus benzylic C-O bond reductive cleavage: synthetic applications

The regioselectivity of the reductive cleavage of 3,4,5-trimethoxybenzyl methyl ether strongly depends on the alkali metal employed as a reducing agent and solvent effects. Reactions run using Na as a reducing agent led to aromatic C(4)-O bond cleavage, whilst reductions run in the presence of Na/15-crown-5, or using Li as a reducing agent, led to highly regioselective benzylic C-O bond cleavage. This regioselectivity turnaround is discussed in terms of major solvent effects affecting the fragmentation paths of a common reaction intermediate. Synthetic applications of these findings led to the synthesis of biologically active compounds, like 2,5-dialkyl-substituted resorcinols, or 1-(3,4,5-trimethoxyphenyl)-2-arylethanes structurally related to combretastatin.