95671-30-0

Basic information

• Product Name: 1-Pyrrolidinamine, N-butylidene-2-(methoxymethyl)-, (2S)-
• CAS NO: 95671-30-0
• Molecular Formula: C10H20N2O
• Molecular Weight: 184.282
• Mol File: 95671-30-0.mol

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinamine, N-butylidene-2-(methoxymethyl)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinamine, N-butylidene-2-(methoxymethyl)-, (2S)-(95671-30-0)
• EPA Substance Registry System: 1-Pyrrolidinamine, N-butylidene-2-(methoxymethyl)-, (2S)-(95671-30-0)

Safety Data

• Hazardous Substances Data: 95671-30-0(Hazardous Substances Data)

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 123-72-8 butyraldehyde 

Downstream Products

• 108439-25-4 (3S,4S)-4-{[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-methyl}-3-phenyl-hexanoic acid methyl ester 

Relevant articles and documents

First asymmetric synthesis of (un)substituted bridged tetrahydro-2-benzazepines

A new and flexible route for the asymmetric synthesis of a variety of alkylated bridged tetrahydro-2-benzazepines has been developed. The key steps are the highly diastereoselective Michael addition of metalated SAMP-hydrazones to α,β-unsaturated esters combined with cyclomethylenation/Mitsunobu coupling reactions to secure the formation of the seven-membered azaheterocycle and of the bridged unit, respectively.

ASYMMETRIC MICHAEL ADDITIONS VIA SAMP-/RAMP-HYDRAZONES ANTI-DIASTEREO- AND ENANTIOSELECTIVE SYNTHESIS OF 3,4-DISUBSTITUTED 5-OXO-ALKANOATES

An efficient and highly anti-diastereo-(de=90-100percent) and enantioselective (ee=92-100percent) synthesis of 3,4-disubstituted 5-oxo-alkanoates 3 in good overall chemical yields is described.The procedure involves the asymmetric Michael addition of aldehydes or ketones to enoates via their lithiated SAMP-/RAMP-hydrazones.Both enantiomers are accessible at will.