95674-68-3Relevant academic research and scientific papers
Synthesis of the Antileucemic Agents 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin
Taylor, Edward C.,Harrington, Peter J.,Fletcher, Stephen R.,Beardsley, G. Peter,Moran, Richard, G.
, p. 914 - 921 (2007/10/02)
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described.These compounds exhibit significant in vivo activity against L1210 leukemia that comparable to that observed with meth
