956903-53-0

Basic information

• Product Name: methyl 2-(4-bromophenylhydrazono)propionate
• CAS NO: 956903-53-0
• Molecular Weight: 271.114
• Mol File: 956903-53-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-bromophenylhydrazono)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-bromophenylhydrazono)propionate(956903-53-0)
• EPA Substance Registry System: methyl 2-(4-bromophenylhydrazono)propionate(956903-53-0)

Safety Data

• Hazardous Substances Data: 956903-53-0(Hazardous Substances Data)

Upstream product

• 600-22-6 pyruvic acid methyl ester 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 1609930-25-7 ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate 
• 210345-56-5 5-bromo-1H-indole-2-carboxylic acid methyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

A novel series of trifluoromethyl indole derivatives have been designed, synthesized and evaluated for anti-HIV-1 activities in MT-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were predicted. Trifluoromethyl indoles 10i and 10k showed extremely promising activities against WT HIV-1 with IC50 values at the low nanomolar level, similar to efavirenz, better than nevirapine, and also possessed higher potency towards the drug-resistant mutant strain Y181C than nevirapine. Preliminary SAR and docking studies of detailed binding mode provided some insights for discovery of more potent NNRTIs. the Partner Organisations 2014.