95694-93-2Relevant academic research and scientific papers
1,1'-binaphthalene-8,8'-diol as en efficient chiral controller: Highly enantioselective synthesis of optically active ketones
Fuji, Kaoru,Yang, Xiao-Shen,Tanaka, Kiyoshi,Asakawa, Naoyuki,Hao, Xiao-Jian
, p. 7373 - 7376 (2007/10/03)
Half esters (R)-5 of 1,1'-binaphthalene-8,8'-diol undergo 1,4-addition of lithium dialkyl cuprates followed by formal 1,2-addition to give β-substituted ketones (S)-6 or (S)-7 with high enantioselectivity (96 ~ 100% ee). A brief discussion of the mechanis
