957060-05-8

Basic information

• Product Name: C₃₈H₄₀N₂O₄S
• CAS NO: 957060-05-8
• Molecular Weight: 620.813
• Mol File: 957060-05-8.mol

Chemical Properties

• CAS DataBase Reference: C₃₈H₄₀N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₄₀N₂O₄S(957060-05-8)
• EPA Substance Registry System: C₃₈H₄₀N₂O₄S(957060-05-8)

Safety Data

• Hazardous Substances Data: 957060-05-8(Hazardous Substances Data)

Upstream product

• 7480-35-5 (1S,2R)-1-amino-2-indanol 

Relevant articles and documents

Discovery of potent HIV-1 protease inhibitors incorporating sulfoximine functionality

Based on the unique property of sulfoximine and the homodimeric C2 structural symmetry of HIV-1 protease, a novel class of sulfoximine-based pseudosymmetric HIV-1 protease inhibitors was designed and synthesized. The sulfoximine moiety was demonstrated to be important for HIV-1 protease inhibitor potency. The most active stereoisomer (2S,2′S) displays a potency of 2.5 nM (IC50) against HIV-1 protease and an anti-HIV-1 activity of 408 nM (IC50). A possible mode of action is proposed.