957062-56-5

Basic information

• Product Name: 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole
• Synonyms: 1-(4-Bromo-1H-pyrazol-1-yl)-4-fluorobenzene
• CAS NO: 957062-56-5
• Molecular Formula: C₉H₆BrFN₂
• Molecular Weight: 241.07
• Product Categories: Azoles;blocks;Bromides;FluoroCompounds
• Mol File: 957062-56-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole(957062-56-5)
• EPA Substance Registry System: 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole(957062-56-5)

Safety Data

• Hazardous Substances Data: 957062-56-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-(4-fluorophenyl)-1H-pyrazole is a chemical compound that belongs to the class of organic compounds known as phenylpyrazoles. It is composed of a bromine atom linked to a pyrazole nucleus that is substituted at position 1 by a 4-fluorophenyl group. The pyrazole's ring involves two nitrogen atoms and forms an aromatic system that contributes to its stability. 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole has not been widely studied but phenylpyrazoles in general exhibit a wide range of biological activities including insecticidal, antibacterial, antifungal, anticancer, and anti-inflammatory properties. However, the individual properties of 4-Bromo-1-(4-fluorophenyl)-1H-pyrazole may vary significantly depending on the precise nature of its chemical structure.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 352-34-1 4-fluoro-1-iodobenzene 
• 81329-32-0 1-(4-fluorophenyl)-1H-pyrazole 
• 2065-75-0 2-Bromo-malonaldehyde 

Downstream Products

• 1251914-10-9 1-(4-fluorophenyl)-4-(thiophen-2-yl)-1H-pyrazole 
• 1156602-69-5 4-amino-1-(4-fluorophenyl)-1H-pyrazole 
• 1469884-13-6 C₂₁H₂₂FN₇ 
• 1373918-57-0 C₁₅H₁₈BFN₂O₂ 
• 877243-13-5 4-(benzo[d][1,3]dioxol-5-yl)-1-(4-fluorophenyl)-1H-pyrazole 

Relevant articles and documents

PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (I), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., lung inflammation, pneumonia, acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), respiratory (e.g., respiratory infection, acute respiratory distress syndrome), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease, inflammatory bowel disease (IBD), ischemic reperfusion injury (e.g., stroke), and retinopathy of prematurity (ROP).

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved by replacement of a six-membered (hetero)aromatic linker with a pyrazole. A short SAR study has delivered key examples with useful in vitro activity and ADME profiles, good selectivity against a human kinase panel and improved levels of lipophilic ligand efficiency. These new analogues thus provide a credible additional route to further development of the series.