957121-38-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-amino-2-(3,5-difluorophenyl)ethanol is used as a chiral auxiliary for the synthesis of pharmaceuticals, leveraging its unique properties to aid in the production of biologically active compounds.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-2-amino-2-(3,5-difluorophenyl)ethanol is employed as a chiral auxiliary, contributing to the synthesis of agrochemicals with enhanced selectivity and efficacy.
Used in Asymmetric Catalysis:
(R)-2-amino-2-(3,5-difluorophenyl)ethanol is utilized as a chiral auxiliary in asymmetric catalysis, where its enantiomeric purity is crucial for achieving desired selectivity in chemical reactions.
Used in the Development of New Drugs:
(R)-2-amino-2-(3,5-difluorophenyl)ethanol serves as a building block in the development of new drugs, capitalizing on its chiral properties to create novel therapeutic agents with improved pharmacological profiles.
Used in Organic Synthesis:
(R)-2-amino-2-(3,5-difluorophenyl)ethanol is used as a chiral building block in organic synthesis, enabling the creation of complex molecules with specific stereochemistry for various applications.

Upstream product

• 1589473-77-7 (R)-4-benzyl-3-((R)-2-bromo-2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one 
• 105184-38-1 3,5-difluorophenyl acetic acid 
• 1589473-79-9 (R)-3-((S)-2-azido-2-(3,5-difluorophenyl)acetyl)-4-benzyloxazolidin-2-one 
• 1589473-80-2 (R)-2-azido-2-(3,5-difluorophenyl)ethanol 
• 957121-37-8 N-[(SS,1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(3,5-difluorophenyl)ethyl]-2-methylpropane-2-sulfinamide 

Downstream Products

• 957121-39-0 2-chloro-N-[(1R)-1-(3,5-difluorophenyl)-2-hydroxyethyl]acetamide 
• 1589473-82-4 (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide 
• 1589473-83-5 (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide 
• 1589473-86-8 (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylthiophene-2-sulfonamide 
• 1589473-88-0 (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynyl)thiophene-2-sulfonamide 
• 1589473-90-4 (R)-5-chloro-N-(cyclopropylmethyl)-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide 
• 1589473-92-6 (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(isobutylcarbamoyl)thiophene-2-sulfonamide 
• 1589473-94-8 (S)-Methyl-2-(3-(5-chlorothiophen-2-ylsulfonyl)-3-((R)-1-(3,5-difluorophenyl)-2-hydroxy-ethyl)ureido)propanoate 
• 1589473-98-2 (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide 
• 1589474-00-9 (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynyl)benzenesulfonamide 
• 1589474-02-1 (R)-4-chloro-N-(cyclopropylmethyl)-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide 
• 1589474-04-3 (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(isobutylcarbamoyl)benzenesulfonamide 
• 1589474-06-5 (S)-methyl 2-(3-(4-chlorophenylsulfonyl)-3-((R)-1-(3,5-difluorophenyl)-2-hydroxyethyl)ureido)propanoate 
• 1589474-08-7 (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynylcarbamoyl)benzenesulfonamide 

Relevant academic research and scientific papers

Difluorophenylglycinols as New Modulators of Proteolytic Processing of Amyloid Precursor Proteins

Synthesis and evaluation of difluorophenylglycinols as new modulators of proteolytic processing of the amyloid-β precursor proteins for Alzheimer's therapies were described. A range of N-substituted (R)- and (S)- difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Evans' chiral auxiliary strategy was employed for the asymmetric synthesis of these enantiomeric difluorophenylglycinols. Compounds with effects on the γ-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. Among them, N-cyclopropylmethyl derivatives R-12c and R-13c showed modest γ-secretase inhibition as well as ERK-dependent activation. A range of N-substituted (R)- and (S)-difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Compounds with effects on γ-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. The N-cyclopropylmethyl derivatives R-12c and R-13c showed modest γ-secretase inhibition and ERK-dependent activation.

Substituted monocyclic CGRP receptor antagonists

Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.