957134-21-3Relevant academic research and scientific papers
Synthesis, structure and in vitro biological activity of new hydroxy-naphthoquinonato triorganotin compounds
Valla, Vasiliki,Bakola-Christianopoulou, Maria,Akrivos, Pericles,Kojic, Vesna,Bogdanovic, Gordana
, p. 765 - 775 (2006)
We report herein on the synthesis, structure and in vitro antitumor activity of new triorganotin compounds of the general type (R 3Sn)nL, where R=Me, Bu, Ph, Bz; L1=5-Hydroxy-1, 4-naphthoquinone; L2=2-Hydroxy-1,4-naphthoquinone; L 3=5,8-dihydroxy-1,4-naphthoquinone; n=1 for L1 & L2 n=2 for L2 and L3. The compounds were synthesized by reacting the triorganotin hydroxide with the parent hydroxy-quinone and were characterized by IR, 1H, NMR, and thermal measurements. The spectroscopic analysis provides evidence on the formation of a chelate ring that is responsible for the stabilization of the triorganotin cation with the Sn central atom in a five-coordinated environment exhibiting distorted trigonal bipyramidal geometry. The new compounds were tested for their cytotoxicity against five human tumor cell lines and one non-tumor human cell line and the results are reported.
