957134-36-0Relevant academic research and scientific papers
Preparation and optimization of a series of 3-carboxamido-5- phenacylaminopyrazole bradykinin B1 receptor antagonists
Dressen, Darren,Garofalo, Albert W.,Hawkinson, Jon,Hom, Dennis,Jagodzinski, Jacek,Marugg, Jennifer L.,Neitzel, Martin L.,Pleiss, Michael A.,Szoke, Balazs,Tung, Jay S.,Wone, David W. G.,Wu, Jing,Zhang, Heather
, p. 5161 - 5167 (2008/03/12)
The B1 receptor is an attractive target for the treatment of pain and inflammation. A series of 3-carboxamido-5-phenacylamino pyrazole B1 receptor antagonists are described that exhibit good potency against B1 and high selectivity over B2. Initially, N-un
4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
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Page column 147, (2008/06/13)
Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
